Clinical characteristics of severe peripheral neuropathy induced by docetaxel (Taxotere)
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چکیده
منابع مشابه
Peripheral neuropathy induced by microtubule-stabilizing agents.
Microtubule-stabilizing agents (MTSAs), including the taxanes and epothilones, are effective chemotherapeutic agents for the treatment of many cancers. Neuropathy is a major adverse effect of MTSA-based chemotherapy, with severe peripheral neuropathy (grade 3 or 4) occurring in as many as 30% of patients treated with a MTSA. MTSA-induced neuropathy usually resolves gradually after cessation of ...
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PURPOSE/OBJECTIVES To review the literature documenting the scope, treatment, and prevention of chemotherapy-induced neuropathy. DATA SOURCES Published abstracts, primary research literature, and textbook chapters. DATA SYNTHESIS Recent improvements in the management of other treatment-related toxicities have led to peripheral neuropathy becoming a dose-limiting toxicity of commonly used ch...
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It has been thought that adult nervous tissues show a remarkable degree of resistance to injury by x rays. Clemedson and Nelson (1960), after a comprehensive review of the literature, state: " Nervous tissues, especially of adult animals, show a remarkable radio-resistance." In the past few years, however, experimental work on animals (Lander, 1959; Innes and Carsten, 1961) suggests that delaye...
متن کاملChemotherapy-induced peripheral neuropathy
Neuropathy is associated with side effects of frontline chemotherapeutics, which is a prominent therapy utilized in prevalent cancers. Peripheral neuropathy negatively impacts quality of life in cancer patients and survivors. It also affects the dose plan of the treatment, thereby limiting the efficacy of the treatment. We searched the electronic database PubMed for pre-clinically and clinicall...
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ژورنال
عنوان ژورنال: Annals of Oncology
سال: 1997
ISSN: 0923-7534
DOI: 10.1023/a:1008245400251